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Rachel M
Reviewed in the United States on February 12, 2025
Pretty sure this is why my dog's liver values are back to normal.
P&D
Reviewed in the United States on December 23, 2024
Use this in conjunction with the current CCNU treatment one of our dogs is on. Vet recommended.
KL
Reviewed in the United States on December 8, 2022
My senior dog had elevated liver values, so we had a liver ultrasound and bile-acid test done to see if her liver was failing. Fortunately, other than high ALP values, everything else was deemed fine. ALP and ALT are the two major types of liver values that vets watch out for. My dog had ALP values near 1000, and normal values for ALT.My vet recommended Denamarin Advanced to lower her liver values. Denamarin Advanced is a prescription only product available at the vet, and it costs $115 per bottle for a 30 day supply/count. It's considered the most effective, even more effective than regular Denamarin available OTC for about ~$60, but it was unavailable because of the pandemic supply shortage. This review is our experience using this Hepato product + SAM-e for months until Denamarin Advanced became available again:The active ingredients for Denamarin Advanced are S-Adenosylmethionine and Silybin-phosphatidylcholine complex. Basically, SAM-e and Silybin. This product has Silybin but no SAMe. To replicate Denamarin, we combined this with a human version of SAMe (from Nature's Trove but can be other brands) since canine products often have a significant markup. Still, in general, when buying human products for dogs, always be careful to research and read reviews to make sure it's safe for dog consumption.We were very conservative with trying off-brand products, so we only fed half of the recommended dosage. As a result, there was no change in bloodwork BUT our dog's symptoms did improve. I can't say for sure, but I believe that had we given the full recommended dosage, my dog's bloodwork would have also improved. My dog's biggest symptoms were very heavy panting, drinking lots of water, and slight weight gain.One sidenote, Denamarin Advanced is given on an empty stomach in the morning, at least 1 hour prior to breakfast for maximum absorption. The instructions for this product say to give with food, but the instructions for SAM-e said to give on an empty stomach. We ended up just giving both together with breakfast to be on the safe side, so our feeding method + half dosage may have affected our results / bloodwork.
Rajan Subramaniam
Reviewed in Singapore on October 21, 2020
Product came on time, well packaged and expiry date is very far.
Binx
Reviewed in the United States on September 2, 2018
About a year and a half- two years ago I took my Chihuahua mix in for his then annual dental cleaning. When I went to pick him up that afternoon I was informed that the labs taken before the procedure indicated that he'd had liver failure. I had noticed no changes in his behavior aside from the fact that he'd suddenly started peeing around the house. I thought he was just "acting out." It never occurred to me that he might actually be sick. Anyhow, it was just fool's luck that we caught it when we did because many pet owners don't catch the disease until it's in its final stages. The vet sold me these exact same vitamins for an obscene amount of money with no indication of how long my minion would need to take them. Some research on the internet clarified that he'd need to take the vitamins for life. Cash was pretty tight back then and I was terrified that I wouldn't be able to afford the treatments. I'm not sure what made me check Amazon to see if I could find the vitamins here. Am I ever grateful I did! The exact same vitamins were much cheaper than the ones I'd previously purchased from my vet and they were shipped right to my door within two days. As for the results, within a week or so of taking the vitamins, my previously mild-mannered dog had the energy of a puppy! When he returned for his follow-up visit 30-days after his diagnosis his labs were back to normal where they've been ever since. He's still doing well (knock on wood!), and has never missed a single dose of this medication. Aside from the fact that I've significantly cut back on his favorite high-fat treats (he loves cheese and peanut butter- never at the same time though), the rest of his diet is pretty much the same as it was prediagnosis. He also gets his teeth cleaned twice a year now just to be extra safe.
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